Targeting the Hypoxia-Sensing Pathway in Clinical Hematology

Analysis of the hypoxia-sensing pathway in Drosophila melanogaster.

The mechanism by which hypoxia induces gene transcription involves the inhibition of HIF-1alpha (hypoxia-inducible factor-1 alpha subunit) PHD (prolyl hydroxylase) activity, which prevents the VHL (von Hippel-Lindau)-dependent targeting of HIF-1alpha to the ubiquitin/proteasome pathway. HIF-1alpha thus accumulates and promotes gene transcription. In the present study, first we provide direct bi...

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF) transcriptional complex. HIF activity is deregulated in many human cancers, especially those that are highly hypoxic. Hypoxic tumour cells are usually resistant to radiotherapy and most conventional chemotherapeutic agents, rendering them highly aggressive and metastatic. Overexpression of HIF-alpha, the ...

Targeting the hypoxia pathway to treat pancreatic cancer

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao's research team ...

Inhibition and Cofactor Targeting of Hypoxia-Sensing Proteins

Clinical Picture in Hematology

To the Editor, I am writing this letter concerning the “Clinical Picture in Hematology” entitled “Isolated Zinc Deficiency Causing Severe Microcytosis and Sideroblastic Anemia” by Shweta et al. in a recent issue of this journal [1]. Although we have seen several cases of zinc and iron deficiency with geophagia, hepatosplenomegaly, growth retardation, and hypogonadism (Tayanç-Reimann-Prasad synd...